Head-to-head AI inference benchmark comparison of B300 (NVIDIA Blackwell) and MI355X (AMD CDNA 4) on Qwen 3.5 397B-A17B. Latency, throughput, and cost across LLM workloads. Use the chart controls below to switch sequences, precisions, and metrics — same interactions as the main inference chart.
AgentX replays real coding-agent sessions rather than fixed-length prompts, so context grows turn over turn and most of each request is served from cache instead of being recomputed. That turns the comparison into a systems question: KV transfer between nodes, prefix-aware routing, and cache capacity all move the curve alongside raw chip throughput. Fixed-sequence workloads stay the clean baseline for kernel and silicon performance, so the two scenarios answer different questions about the same hardware. Learn more about AgentX →
Setting 101 tok/s/user as the target on Qwen 3.5 397B-A17B, B300 produces 47252 tok/s/chip ($0.01 per million tokens) and MI355X produces 36990 ($0.01). MI355X is 18% cheaper per token; B300 delivers 28% more tok/s/chip.
At 172 tok/s/user interactivity on Qwen 3.5 397B-A17B, B300 delivers 22692 tok/s/chip at $0.03 per million tokens; MI355X delivers 20709 tok/s/chip at $0.02. MI355X is 37% cheaper per token; B300 delivers 10% more tok/s/chip at this point.
B300 posts 16670 tok/s/chip for $0.04 per million tokens at 243 tok/s/user on Qwen 3.5 397B-A17B; MI355X posts 5902 tok/s/chip for $0.07. B300 is 87% cheaper per token; B300 delivers 182% more tok/s/chip. (Numbers reflect the default agentic-traces · fp8 selection for this URL — table and chart below update if you change sequence, precision, or model in the controls.)
| Metric | Interactivity (tok/s/user) | Interactivity (tok/s/user) | Interactivity (tok/s/user) |
|---|---|---|---|
| Throughput (tok/s/chip) | B300:47252.0MI355X:36990.3 | B300:22692.2MI355X:20708.9 | B300:16670.2MI355X:5902.4 |
| Cost ($/M tok) | B300:$0.013MI355X:$0.011 | B300:$0.028MI355X:$0.020 | B300:$0.038MI355X:$0.071 |
| tok/s/MW | B300:24869492MI355X:17698723 | B300:11943241MI355X:9908570 | B300:8773789MI355X:2824119 |
| Concurrency | B300:~45MI355X:~30 | B300:~17MI355X:~14 | B300:~22MI355X:~4 |
Agentic inference metrics from the AgentX scenario and fixed-sequence inference metrics across models, hardware configurations, and serving parameters.
TCO $/chip/hr:
Source: SemiAnalysis Market July 2026 Pricing Surveys & AI Cloud TCO Model
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate cost per million tokens per decode chip or per prefill chip, rather than per total chip count. This makes direct token cost comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate input throughput per decode chip or per prefill chip, rather than per total chip count. This makes direct input throughput comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate output throughput per decode chip or per prefill chip, rather than per total chip count. This makes direct output throughput comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate power per decode chip or per prefill chip, rather than per total chip count. This makes direct power comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate Joules per decode chip or per prefill chip, rather than per total chip count. This makes direct Joules per token comparison with aggregated configs not an apples-to-apples comparison.
Matching measurements exist, but their chip series are hidden.
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1 The ATOM engine is promising, however it has yet to serve production tokens. It is still in its infant stage.
Qwen3.5 397B 8K / 1K Total Tokens per $1 TCO vs. Interactivity