Qwen 3.5 397B-A17B — B300 vs MI300X
Head-to-head AI inference benchmark comparison of B300 (NVIDIA Blackwell) and MI300X (AMD CDNA 3) on Qwen 3.5 397B-A17B. Latency, throughput, and cost across LLM workloads. Use the chart controls below to switch sequences, precisions, and metrics — same interactions as the main inference chart.
AgentX replays real coding-agent sessions rather than fixed-length prompts, so context grows turn over turn and most of each request is served from cache instead of being recomputed. That turns the comparison into a systems question: KV transfer between nodes, prefix-aware routing, and cache capacity all move the curve alongside raw chip throughput. Fixed-sequence workloads stay the clean baseline for kernel and silicon performance, so the two scenarios answer different questions about the same hardware. Learn more about AgentX →
B300 posts 55593 tok/s/chip for $0.01 per million tokens at 9 tok/s/user on Qwen 3.5 397B-A17B; MI300X posts 3270 tok/s/chip for $0.08. B300 is 615% cheaper per token; B300 delivers 1600% more tok/s/chip.
Throughput at 9 tok/s/user on Qwen 3.5 397B-A17B: B300 hits 55593 tok/s/chip, MI300X hits 3270. Per-million costs land at $0.01 and $0.08 respectively. B300 is 615% cheaper per token; B300 delivers 1600% more tok/s/chip.
B300 / MI300X on Qwen 3.5 397B-A17B at 10 tok/s/user: 55593 / 3085 tok/s/chip, $0.01 / $0.09 per million tokens. B300 is 657% cheaper per token; B300 delivers 1702% more tok/s/chip. (Numbers reflect the default agentic-traces · fp8 selection for this URL — table and chart below update if you change sequence, precision, or model in the controls.)
| Metric | Interactivity (tok/s/user) | Interactivity (tok/s/user) | Interactivity (tok/s/user) |
|---|---|---|---|
| Throughput (tok/s/chip) | B300:55593.4MI300X:3270.0 | B300:55593.4MI300X:3270.0 | B300:55593.4MI300X:3085.3 |
| Cost ($/M tok) | B300:$0.011MI300X:$0.081 | B300:$0.011MI300X:$0.081 | B300:$0.011MI300X:$0.086 |
| tok/s/MW | B300:29259710MI300X:2352546 | B300:29259710MI300X:2352546 | B300:29259710MI300X:2219668 |
| Concurrency | B300:~32MI300X:~23 | B300:~32MI300X:~23 | B300:~32MI300X:~20 |
Inference Performance
Agentic inference metrics from the AgentX scenario and fixed-sequence inference metrics across models, hardware configurations, and serving parameters.
Total Tokens per $1 USD (Owning - Hyperscaler) vs. Interactivity
Qwen3.5 397B • FP4 • 8K / 1K • Source: SemiAnalysis InferenceX™
TCO $/chip/hr: H100: 1.17H200: 1.22B200: 1.73B300: 2.26GB200: 1.86GB300: 2.31MI300X: 0.95MI325X: 1.1MI355X: 1.5RTX6000PRO: 0.68
Source: SemiAnalysis Market July 2026 Pricing Surveys & AI Cloud TCO Model
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate cost per million tokens per decode chip or per prefill chip, rather than per total chip count. This makes direct token cost comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate input throughput per decode chip or per prefill chip, rather than per total chip count. This makes direct input throughput comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate output throughput per decode chip or per prefill chip, rather than per total chip count. This makes direct output throughput comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate power per decode chip or per prefill chip, rather than per total chip count. This makes direct power comparison with aggregated configs not an apples-to-apples comparison.
Note: Disaggregated inference configurations (e.g., MoRI SGLang, Dynamo TRTLLM) calculate Joules per decode chip or per prefill chip, rather than per total chip count. This makes direct Joules per token comparison with aggregated configs not an apples-to-apples comparison.
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